Deadly Liver Mob project in hepatitis C and sexual health Hide

Chief Investigator:
Dr. Carla Treloar

The Deadly Liver Mob Project (DLM) was an initiative of the Western Sydney Local Health District Harm Reduction team. The project came about as a result of poor attendances at the needle and syringe program by Aboriginal people and very few episodes of care over the immediate preceding years in the adjacent sexual health clinic, despite the area being one of the most populous areas for Aboriginal people in Australia. The DLM incorporates a peer driven intervention [PDI] with incentives provided for each step in participation to encourage people to be educated about BBV and then recruit and educate their peers as well as consider offers of hepatitis C and sexual health screening. Evaluation of the DLM in Western Sydney and the new site in Nepean Blue Mountains Local Health Districts will be undertaken using a non-experimental mixed-method design.

The overall aims of the evaluation are:

  • To evaluate the long term translation, uptake and sustainability of sexual health service delivery associated with the DLM
  • Identify long term prevention, care and treatment pathways for Aboriginal people as a result of the DLM;
  • To examine the acceptability and implications for roll-out and scale-up of the DLM among DLM clients, LHDs workers and managers

This evaluation is supported by BRISE and the two participating health districts

The PrEPARE Project Hide

Chief Investigator:
Dr. Martin Holt

This project aims to investigate the attitudes of gay and bisexual men to new HIV prevention technologies, particularly pre-exposure prophylaxis (PrEP) and treatment as prevention. The main method of data collection is a national, online survey of gay and bisexual men which has been repeated every two years since 2011.

Study website

To view the 2015 report, please click here.

 

Sydney Gay Community Periodic Survey Hide

Chief Investigator:
Dr. Martin Holt

The Sydney Gay Community Periodic Survey is a cross-sectional survey of gay and homosexually active men recruited at a range of gay community sites in Sydney. In 2015, online recruitment was included for the first time. Since 1996, the project has been funded by the NSW Ministry of Health and supported by ACON and Positive Life NSW. The major aim of the survey is to provide data on sexual, drug use and testing practices related to the transmission of HIV and other sexually transmissible infections (STIs) among gay men in Sydney. Reports on previous rounds of the survey can be accessed at https://csrh.arts.unsw.edu.au/research/publications/gcps/

StraightMSM Study: Heterosexually-identified men who have sex with men Hide

Chief Investigator:
Dr. Christy Newman, Dr. Asha Persson

The primary focus of this exploratory, qualitative project, funded by BRISE, was to interview a range of professionals employed in health services, health promotion and other relevant roles to document their expert views on the experiences and needs of straight-identified MSM in New South Wales. Other activities included reviewing the literature, analysing existing CSRH data, and appraising the terminology and activities evident in online personal ads posted by straight MSM.

Publications can be accessed at https://csrh.arts.unsw.edu.au/research/projects/straight-msm/

Updating incidence and prevalence modelling of infection and disease burden for hepatitis B and C Hide

Chief Investigator:
Dr. Richard Gray

 

Injecting drug use (IDU), and opioid dependence, are thought to be significant contributors to the burden of disease in Australia and globally. Much of the burden derives from the increased risks of blood-borne virus transmission due to unsafe drug injection, with elevated risks of hepatitis C (HCV) and hepatitis B (HBV) among people who inject drugs (PWID). Updated estimates of the population size of PWID, and the incidence and prevalence of hepatitis C and hepatitis B, are proposed. PWID sampled in surveillance studies are becoming older, fewer people may be initiating to heroin use following the heroin shortage of 2001, and the types of drugs being injected by those who do still inject have shifted. Such shifts may influence the trajectory of blood-borne virus (BBV) epidemics in Australia, so it is crucial that new population size estimates are available to inform such projections and that out-dated estimates and projections are conducted.

NSW Health has provided funding to the Kirby Institute to coordinate and conduct studies to:

  • estimate the number of PWID, nationally, by each state and territory, and by local health district (LHD) for NSW;
  • estimate the prevalence, incidence and disease burden of hepatitis B, by region (as specified in (1)) and project future epidemic trajectories;
  • estimate the prevalence, incidence and disease burden of hepatitis C, nationally and by region (as specified in (1)) and project future epidemic trajectories.

 

Download the report

NSW Needle and Syringe Program Enhanced Data Collection Hide

Chief Investigator:
Professor Lisa Maher, Dr Jennifer Iversen

The NSW Needle and Syringe Program Enhanced Data Collection (NNEDC) provides a coordinated state-wide mechanism to collect and analyse data from people who inject drugs (PWID) who attend public sector Needle and Syringe Programs (NSPs). The NNEDC provides key data on priority populations and injection risk behaviour, monitors trends in the NSP population, and contributes to surveillance and performance in meeting the targets outlined in  the NSW HIV Strategy 2012-2015 and the NSW Hepatitis B and C Strategies 2014 -2020. The  NNEDC was implemented in 2004 and 2008 and for four consecutive years, 2013 to 2016. This BRISE project will conduct the NNEDC for a fifth consecutive year (2017).

 

 

The Blood borne virus (BBV) and sexually transmitted infection research intervention and strategic evaluation - Aboriginal systems project (BRISE ASP) Hide

Chief Investigator:
Dr Marlene Kong, A/Prof Rebecca Guy, Professor Carla Treloar

Co-investigator: Dr Monika Wadolowski

BRISE ASP aims to gather evidence of current and past strategies for STI and BBV management within NSW Aboriginal community controlled health services (ACCHS), and assess the strength of these strategies for increasing in STI/BBV testing, management and health outcomes. Strategies considered for BRISE ASP will include prevention programs, health promotion programs, and projects supporting clinical staff to achieve best practice in testing and management. BRISE ASP will also consider strategies led by ACCHS, peak bodies (e.g. AH&MRC), local health districts (LHDs), and other collaborators. The findings from BRISE ASP will help inform future strategies and programs for STI/BBV management in ACCHS settings. BRISE ASP will explore the potential for multiple strategies to be combined, or opportunities to involve partnerships, such as ACCHS and local health districts (LHDs) to maximise the effectiveness and sustainability of future programs.

Surveillance of hospitalizations, hepatocellular carcinoma and mortality among people diagnosed with hepatitis C or hepatitis B virus infection in New South Wales: a population-based linkage study Hide

Chief Investigator:
Professor Gregory Dore, A/Prof Jason Grebely, Dr Maryam Alavi, A/Prof Janaki Amin, Prof Matthew Law, A/Prof Gail Matthews, Dr Behzad Hajarizadeh

 

HBV and HCV notifications (1993-2012), held by the Notifiable Conditions Information Management System, have been linked (by CHeReL) to several datasets, including HIV administrative dataset (from 1985), the Pharmaceutical Drugs of Addiction System administrative database (from 1985), NSW Admitted Patient Data Collection (from 2001), NSW Central Cancer Registry (from 1994), NSW Registry of Births Deaths and Marriages (from 1993), and Cause of Death Unit Record File (from 1993). Future linkages will also include NSW Perinatal Data Collection (from 1994), NSW Bureau of Crime Statistics and Research (from 1994), NSW Emergency Department Data Collection (from 2005), Pharmaceutical Benefits Scheme (PBS) (from 2010), and Medicare Benefits Schedule (MBS) (From 2010). Linkages to PBS and MBS will be carried out by AIHW. This project will also utilize these datasets to improve the reporting of Aboriginal and Torres Strait Islander peoples within the study. The next round of data linkage is expected to occur mid-2017.   

The BRISE linkage project has the capacity to provide ongoing evaluation of the impact of new HBV and HCV treatments on population-level liver disease burden, and inform HBV and HCV care cascades, including among Aboriginal and Torres Strait Islander peoples.

New South Wales Sex Worker Health Surveillance Project Hide

Chief Investigator:
Professor Basil Donovan

 

Those who sell sex (sex workers) have been identified in a priority population in state and national strategies for the prevention of HIV and other sexually transmissible infections. This project monitors trends in sexual health testing, diagnoses and treatment among sex workers in New South Wales and provides details on characteristics pertaining to the health of sex workers in the state. In 2016, the project used data collected from publicly-funded sexual health clinics to assess the prevalence and incidence of HIV, chlamydia, gonorrhoea, and infectious syphilis among sex workers and produced a report (see below). A more detailed analysis of HIV/STIs in male sex workers determined that involvement in sex work was not an independent risk factor for infections in gay and bisexual men (Callander D, et al. Sexually Transmitted Infections 2017 [in press]).

A molecular epidemiology study that was published in 2016 confirmed that gonorrhoea had recently re-emerged as an endemic STI among heterosexuals in NSW.  The role that female sex work – and oral sex, in particular – plays in this re-emergence is currently under investigation with the cooperation of the Ministry of Health, SWOP, and clinical services.

Report
Callander D, Cox C, Schmidt H, Donovan B. Sex Worker Health Surveillance: a Report to the New South Wales Ministry of Health. 2015. Sydney, NSW: Kirby Institute.
Download the report

Enhancing existing sexual health surveillance systems to monitor STI and hepatitis strategies in NSW Hide

Chief Investigator:
Dr Denton Callander, Professor Basil Donovan, Professor Greg Dore, Associate Professor Jason Grebely, Professor Margaret Hellard, Associate Professor Rebecca Guy

 

In New South Wales, strategies for the control of STIs and hepatitis highlight the need for targeted surveillance and monitoring of these infections, particularly among populations most at-risk. Data for this project are routinely collected patient data extracted via the ACCESS Project (Australian Collaboration for Coordinated Enhance Sentinel Surveillance) from sexual health clinics, hospital infectious diseases clinics, general practices and pathology laboratories across the state. The indicators produced from these data are used to monitor testing, diagnosis and management of STIs and hepatitis – including among priority populations – and play an important part in the state’s overall surveillance and monitoring mechanisms.

Monitoring and understanding HIV treatment initiation and adherence Hide

Chief Investigator:
Associate Professor Garrett Prestage

Co-investigator: Ian Down
 
The first stage of this work involves mapping the current referral pathways for people newly diagnosed with HIV. Through this we aim to identify where monitoring clinical data needs expansion, and if existing community-based and clinical pathways are sufficient to ensure data collection is efficient and consistent across jurisdictions and between settings. This research will allow improvements to communication, client services, and better clinical and personal outcomes for people diagnosed with HIV.
 
We will liaise with state health departments, relevant community organisations and select clinical services in each jurisdiction, including in specific non-urban locations where feasible, to map the current follow-up procedures applicable to individuals who have been newly diagnosed with HIV. We will map current clinic based procedures for post-diagnosis counselling and clinical blood work testing, treatment initiation protocols, referrals to community and peer support services, as well as data collection and reporting within and between clinic-based and community-based services. We will map current procedures in community organisations for counselling, community and peer support services, referrals to clinical services, as well as data collection and reporting within and between clinic and community- based services. We will also review the current surveillance mechanisms, in each jurisdiction with the aim of assessing how these mechanisms either dissuade or facilitate the patient trajectory between the clinic and community based services.
 

Assessing the robustness of the NSW NSP Enhanced Data Collection Hide

Chief Investigator:
Professor Lisa Maher, Dr Jenny Iversen

 

The robustness or the degree of external validity of results from the NSW NSP Enhanced Data Collection (NNEDC) is difficult to determine. A key limitation is the lack of information that is collected from NSP clients who decline to participate in the NNEDC, particularly in terms of demographic characteristics and injecting risk behaviour. However, while the NNEDC is designed to remove the need to request data of NSP clients on each occasion of service by replacing this with an annual snapshot data collection, this collection aims to place as few demands as possible on respondents who are not reimbursed for their participation.

The current study aims to assess the robustness of the NNEDC by determining the representativeness of respondents relative to the broader population of NSW NSP clients by comparing basic demographic (age, gender, Indigenous status) and drug use (self-reported drug last injected) characteristics. The 2017 NNEDC will include a mandatory core module to be completed by all presenting NSP clients. Data will be analysed using STATA to model univariate and multivariate associations between demographic and drug use characteristics and completion of the NNEDC survey. Wald X2 tests and related 95% confidence intervals (CIs) will be calculated to assess statistical significance and precision.

ETHOS and LiveRLife – contribution of peer education Hide

Chief Investigator:
Professor Greg Dore, Associate Professor Jason Grebely, Dr Mary-Ellen Harrod, Yvonne Samuel

 

A collaboration between Kirby Institute and NUAA is developing educational materials and workshop to train peer workers in hepatitis C. The educational program will cover HCV epidemiology and natural history, HCV prevention, and treatment with direct-acting antiviral regimens. Peer workers, including those involved in Kirby-related research projects, will undertake the program to enhance evidence-based peer education of people who inject drugs.  

Modelling hepatitis C treatment uptake to enhance treatment delivery Hide

Chief Investigator:
Dr. Richard Gray
This project extends the incidence and prevalence modelling of hepatitis C project to investigate what level of treatment is required and in what settings to achieve the WHO elimination targets for hepatitis C in each local health district in NSW.

Estimating the prevalence, incidence and disease burden of hepatitis C for Aboriginal people Hide

Chief Investigator:
Dr. Richard Gray
Aboriginal Australians are disproportionately affected by hepatitis C. Through close consultation with Indigenous stakeholders this project will collate the best available data on hepatitis C epidemiology in the Aboriginal community and use best practise epidemiological modelling methods to estimate to estimate the prevalence, incidence and associated disease burden of hepatitis C for Aboriginal people nationally, in each jurisdiction, and for NSW local health districts.